Many moms with PCOS have no problems with breastfeeding, but recent research is showing that mothers with PCOS are at greater risk for insufficient milk supply. On the other hand, about one-third of women with PCOS report problems with oversupply (perhaps this is connected with the hyperprolactinemia – elevated prolactin levels – that occurs in about 20% of moms with PCOS).
Polycystic ovarian syndrome and breastfeeding, from the Australian Breastfeeding Association
Polycystic Ovary Syndrome (PCOS) and Breastfeeding by Nancy Howat BSc (Hons), and Hilary Jacobson, CH.HU.SI.
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Insulin resistance and lactation insufficiency: FAQ by Diana Cassar-Uhl, MPH, IBCLC
Cincinnati Children’s Hospital Medical Center. “Why some women don’t have enough breastmilk for baby: Important role of insulin in making breast milk identified.” ScienceDaily. ScienceDaily, 5 July 2013.
Danielle G. Lemay, Olivia A. Ballard, Maria A. Hughes, Ardythe L. Morrow, Nelson D. Horseman, Laurie A. Nommsen-Rivers. RNA Sequencing of the Human Milk Fat Layer Transcriptome Reveals Distinct Gene Expression Profiles at Three Stages of Lactation. PLoS ONE, 2013; 8 (7): e67531
Neville MC, Webb P, Ramanathan P, Mannino MP, Pecorini C, Monks J, Anderson SM, MacLean P. The insulin receptor plays an important role in secretory differentiation in the mammary gland. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1103-14. doi: 10.1152/ajpendo.00337.2013. Epub 2013 Aug 27.
Vanky E, Nordskar J, Leithe H, Hjorth-Hansen A, Martinussen M, Carlsen S. Breast size increment during pregnancy and breastfeeding in mothers with polycystic ovary syndrome: a follow-up study of a randomised controlled trial on metformin versus placebo. BJOG. 2012 Jul 25. doi: 10.1111/j.1471-0528.2012.03449.x. [Epub ahead of print]
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Vanky E, IsaksenH, Moen MH, Carlsen SM. Breastfeeding in polycystic ovary syndrome. Acta Obstet Gynecol Scand 2008;87(5):531-5.
Feig DS, Briggs GG, Koren G. Oral antidiabetic agents in pregnancy and lactation: a paradigm shift? Ann Pharmacother. 2007 Jul;41(7):1174-80. Epub 2007 May 29.
Glueck CJ, Wang P. Metformin before and during pregnancy and lactation in polycystic ovary syndrome. Expert Opin Drug Saf. 2007 Mar;6(2):191-8.
Nesmith H. Polycystic Ovarian Syndrome (PCOS) and Lactation. Topics In Breastfeeding Set XVIII, Lactation Resource Centre, 2006 (November).
Glueck CJ, Salehi M, Sieve L, Wang P. Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome. J Pediatr. 2006 May;148(5):628-632.
Briggs GG, Ambrose PJ, Nageotte MP, Padilla G, Wan S. Excretion of Metformin Into Breast Milk and the Effect on Nursing Infants. Obstet Gynecol 2005;105:1437-1441.
Baillargeon J, Jakubowicz D, Iuorno M, Jukubowicz S, Nestler J. Effects of metformin and rosiglitazone, along and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity. Fertil Steril 2004;82(4):893-902.
Hale TW, Kristensen JH, Hackett LP, Kohan R, Ilett KF. Transfer of metformin into human milk. Diabetologia 2002;45:1509–1514.
Marasco L, Marmet C, Shell E. Polycystic Ovary Syndrome: A Connection to Insufficient Milk Supply? J Hum Lact 2000;16(2):143-8.